TRPC 3 Mediates Hyperexcitability and Epileptiform Activity in Immature Cortex and 1 Experimental Cortical Dysplasia
نویسنده
چکیده
TRPC3 Mediates Hyperexcitability and Epileptiform Activity in Immature Cortex and 1 Experimental Cortical Dysplasia 2 3 Fu-Wen Zhou*, and Steven N. Roper 4 Departments of Neurosurgery and the McKnight Brain Institute, 5 University of Florida 6 7 Running Head: TRPC3 in cortical dysplasia 8 9 10 *Corresponding Author: 11 Fu-Wen Zhou, M.D., Ph.D. 12 Department of Neurosurgery 13 University of Florida 14 1149 South Newell Drive, Room L2-100 15 Gainesville, FL 32610 16 Phone: 352-273-9000 17 Fax: 352-392-8413 18 E-mail: [email protected] 19 20 21 Articles in PresS. J Neurophysiol (December 18, 2013). doi:10.1152/jn.00607.2013
منابع مشابه
TRPC3 mediates hyperexcitability and epileptiform activity in immature cortex and experimental cortical dysplasia.
Neuronal hyperexcitability plays an important role in epileptogenesis. Conditions of low extracellular calcium (Ca) or magnesium (Mg) can induce hyperexcitability and epileptiform activity with unclear mechanisms. Transient receptor potential canonical type 3 (TRPC3) channels play a pivotal role in neuronal excitability and are activated in low-Ca and/or low-Mg conditions to depolarize neurons....
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